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Why choose MKPEP’ peptide synthesis services?

End-to-End Manufacturing of Peptides, from Simple to Complex, Crude to GMP and up to Multikilogram Scale

We specialize in meeting our customer’s needs and delivering the highest quality and service. Our experienced synthetic chemists work in collaboration with customers to understand their needs, whether that be a single, simple peptide, a variety of complex labeled products or an extensive library for screening. We are also proud to have specialist teams in our large-scale production facility to manufacture at multikilogram scale. we have the capability and expertise to perform a wide variety of chemistries.

We work in our high-quality R&D lab and GMP facilities. We provide innovative solutions for lead discovery, rapidly produce peptides for screening, and can support your regulatory needs, all with excellent customer service.

Our Peptide team provides support from lead discovery and optimization phase through to supply of GMP peptides or bulk quantities. But we also excel at the rapid custom synthesis of peptides for research, as well as having an extensive selection of catalog peptides ready to go.

Included in your custom peptide synthesis order
PEPTIDE SYNTHESIS METHOD

Fmoc solid-phase synthesis (standard)

GMP peptide synthesis (upon request)

QUANTITY

From 1 mg to 1 kg

PURITY

Crude to≥98%

TFAremoval upon request

LEAD TIME

Starting from 10 business days

Shipping

Ambient temperature

Peptide order

Lyophilized peptide and corresponding QC report

Standard QC report

Amino acid sequence

Purity and quantity information

Modification and conjugation information

MS and HPLC profiles (except for crude/desalted peptides)

Additional analysis (upon request)

Net peptide content analysis (N%)

Qualitative amino acid analysis (AAA)

Water content analysis

Ion chromatography analysis (TFA, HAC)

Solvent residue (DMF, ACN)

Endotoxin (<1EU/MG)

Major applications of synthetic peptides
Peptide drugs
Many peptide drugs are generated by chemical modification of natural molecules. These drugs remain invaluable for the treatment of multiple metabolic diseases.
Peptide vaccines
Vaccines are considered one of the most successful strategies of modern medicine. Conventional vaccines have relied heavily in inactive pathogens to elicit an immune response, making them hard to produce.
Peptides for tissue engineering
The discovery of cell adhesion and self-assembling peptides has opened up a new window of opportunity in tissue engineering applications.
Drug & Gene Delivery
Cell-penetrating peptides and self-assembling peptides are two increasingly important bioactive components of advanced gene and drug delivery applications .
Most widely used peptide synthesis methods
Chemical synthesis

Solid-phase synthesis

Liquid-phase synthesis

Native chemical ligation

Recombinant expression

Bacterial systems ( coliand B. subtilis)

Yeast systems ( cerevisiaeand P.pastoris)

Mammalian or insect cell lines

Semisynthesis
Combination of synthetic and recombinant fragments via chemical or enzymatic ligation
Useful guidelines for working with synthetic peptides
How to test the solubility of your custom synthetic peptide
The most commonly used method to test solubility is based on charge determination. For small peptides with up to 5 amino-acids, distilled water remains the first option. For other cases, you can refer to this guide:
Attribute -1 to each acidic residue (Asp / D, Glu / E) and to the terminal carboxylic acid. Then, assign +1 to each basic residues (Arg / R, Lys / K, His/h) and the terminal amine. Sum up both values to determine the overall charge of your peptide.
If the overall charge value is positive, try to dissolve your peptide in water. In case the peptide does not dissolve, acidify your solution with an acetic acid solution (10 to 30%). Add TFA if acetic acid does not allow peptide dilution du sufficient concentration.
In case the overall charge is negative and the peptide does not contain cysteine residues, try to dissolve your peptide in water. If the peptide does not dissolve, add ammonium hydroxide to obtain the desired concentration.
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Get a free quote
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